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And in the MCAS case series, most patients who stopped their GLP-1RA (whether due to cost, unavailability, or curiosity about what would happen) experienced a return of the symptoms that had been controlled

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Second, the gut can act independently as if it has a mind of its own: due to local reflex circuits, the ENS is capable of functioning with and without input from the central nervous system (Fleming II et al., 2020)

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These recent trials have shown some promise for the use of GLP-1 RA in patients with neurodegenerative conditions and movement disorders, which may have implications for their use as augmentative therapies along with neurosurgical treatments such as deep brain stimulation, as well as high intensity focus ultrasound

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