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C-terminal fragment lipolytic domain isolated from the parent hormone Beta-3 adrenergic signaling elevated adipocyte cyclic AMP Hormone-sensitive lipase activation triglyceride hydrolysis Absent somatogenic domain no IGF-1 elevation in published models N-terminal tyrosine stability modification over the unmodified fragment Core Areas of Scientific Investigation Structure-Function Mapping: AOD-9604 helps localise the lipolytic domain of growth hormone within its 191-residue sequence

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Its striking structural feature is charge density: a high proportion of lysine and glutamate residues in a very short chain, no aromatic residues, no cysteines, no hydrophobic core, and no stable secondary structure when free in aqueous solution

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