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GLP-1s are serious medications with certain potential toxicities for some patients, including pancreatitis, thyroid cancer, and very rarely, but now officially acknowledged in the case of Wegovy blindness, caused by a condition called non-arteritic anterior ischemic optic neuropathy (NAION)
In fact, emerging clinical data indicates that semaglutide may be associated with increased testosterone levels in certain populations, particularly in men with obesity and low baseline testosterone
Safety: Both medicines can cause gastrointestinal side effects and need clinical review
NICE has not yet issued technology appraisal guidance or clinical guidelines specific to retatrutide, given its investigational status
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