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Patients with T2DM experience a significant decline in the incretin function causing delayed and reduced insulin release after glucose administration, impairing glucose tolerance [12,13,14]

Weight management : Modest weight loss (5-10% of body weight) in individuals with overweight or obesity can improve metabolic parameters and potentially enhance endogenous GLP-1 activity

In 1957, Jean Stern physician and clinical pharmacologist published the results of a study on the antidiabetic properties of several biguanides

Injection Site Complications Another potential riskand one thats often overlookedis the localized complications associated with injectable peptides