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They have been extensively explored as multifunctional nanoplatforms, showing great promise in various applications such as biosensing, bioimaging, and drug delivery [5, 6]
While the regulation of MTHFR activity is closely controlled by SAM at C-terminal regulatory domain, more studies indicated that the human MTHFR enzyme activity is also regulated by multiple phosphorylated sites on a serine-rich N-terminal extension region 20
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