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With the implicit validity of these data given the expected weight regain seen after therapy cessation, there is some credence to the idea that this is a genuine reflection of nondurability of weight loss with GLP-1 receptor agonist therapy

The Phase 2 results published in the New England Journal of Medicine generated significant buzz, and the TRIUMPH-4 Phase 3 confirmation elevated that interest further

They showed up consistently

Whether treatment should be ended depends, among other things, on tolerability, blood pressure, pulse, possible interactions, and the course of treatment so far, and should always be decided by a doctor