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During anaplerosis, mitochondrial glutamate dehydrogenase 1 (GLUD1) plays a key role by catalyzing the conversion of glutamate to alpha-ketoglutarate (-KG) and releasing ammonia, which regulates autophagy and neutralizes the intracellular pH in cancer cells 19,20

Livingstone, the missionary explorer famous for his journeys through Africa, survived using quinine to combat malaria.[ref] Quinine can be transferred to breast milk