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The GRADE Working Group

Pfizer's Phase 2b results, presented at the American Diabetes Association meeting in 2023, showed that danuglipron produced dose-dependent weight loss and HbA1c reductions in patients with type 2 diabetes, though with significant gastrointestinal tolerability challenges at higher doses

In a Phase 1 first-in-human study, MK-1167 increased glutamate metabolism in the brains prefrontal cortex, crucial for cognitive functions like decision-making, memory, and emotional regulation