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This result warrants caution: oral bioavailability of hexapeptides is generally very low due to gastrointestinal degradation and poor intestinal absorption, and the finding has not been widely replicated or supported by pharmacokinetic data confirming systemic absorption at meaningful levels

It is because there are no clinical trial data to inform a recommendation either way

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Discontinuation was more common among Black or Hispanic patients, males, Medicare or Medicaid enrollees, those living in areas with high social needs, and patients with obesity, heart failure, or other cardiovascular conditions