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The latest diabetic retinopathy preferred practice guidelines from the American Academy of Ophthalmology indicate that the rising use of GLP-1RAs may lead to quick glycemic control and severe hypoglycemia and has been reported to cause higher rates of retinopathy complications, especially in patients with early-stage DR (Lim et al., 2025)

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Common scenarios include: Sitting on a pharmacy counter during processing Transport from pharmacy to home without insulation Power outage affecting your refrigerator Accidental placement in a freezer compartment Leaving the pen out after an injection Travel without proper cooling Each temperature excursion accumulates

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