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Primary hyperaldosteronism, an adrenal disorder, is often a result of adrenal hyperplasia or tumors, and is associated with several cardiovascular and kidney risks
In diabetes mellitus, elevated cytosolic Ca 2+ levels directly impair platelet mitochondrial health by overwhelming the MCU/VDAC uptake system, causing matrix Ca 2+ overload that opens mPTP pores, collapses m, and unleashes ROS/cytochrome c-driven apoptosis alongside prothrombotic hyperactivity (Wang et al., 2025)
Stipanuk, M
J.Mazandaran Univ.Med.Sci
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