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Muscle: 250 to 500 mcg once or twice daily, subcutaneous near the muscle, 4 to 8 weeks
Crucially, the gut microbiome is essential for priming this response, as germ-free mice do not develop P.g -specific Th17 cells or severe periodontitis upon challenge, a response that is restored upon microbiota recolonization (Nagao et al., 2022)
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