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Rachel Nania es una galardonada editora que escribe sobre atencin mdica y polticas de salud para AARP.

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418 Rechallenge strategies, by contrast, operate under the premise of clonal evolution reversibility, whereby reintroducing previously used agents, often after a drug holiday, can resensitize tumors due to regrowth of drug-sensitive clones

however, the progression from low-grade PanINs to PDAC involves sustained proliferation leading to the accumulation of somatic mutations and typically spans for longer than a decade 20,31