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Using the same assumptions as the Life Sciences Report, we forecast that existing future mortality improvement expectations could be supported by the impact of obesity drugs

The lack of FDA approval for human use and the need for higher doses in some experimental settings underscore the importance of evaluating safety and efficacy under strict medical supervision

The foundational evidence is a 2017 Cell study in aged and progeroid mice , where FOXO4-DRI reduced senescent-cell burden and restored markers such as fur density and renal function [3]