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People who have a history or family history of a rare thyroid cancer (medullary thyroid carcinoma) should not use this medication, says Gudzune

The injectable form provides the most direct path to therapeutic tissue levels

To explain the effect, the researchers suggested that the drugs anti-inflammatory and metabolic effects, such as improved insulin sensitivity, may contribute to improved outcomes Body fat, or adipose tissue, is metabolically active, pumping out hormones and inflammatory cytokines than could promote the development and progression of cancer

Dose optimization requires integrating blood work data with clinical response (weight trajectory, appetite, side effects, energy levels)