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Critically, research by Leal-Cerro and colleagues confirmed that endogenous GHRH is required for most of the GH response to GHRP-6, demonstrating that GHRPs work synergistically with the hypothalamic GHRH system rather than independently from it

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The compound has been found to operate in the postrema and nucleus of the hindbrain solitary tract in order to both induce satiety and regulate appetite by acting on receptors found in the laterodorsal tegmental nucleus, ventral tegmental area, and the hypothalamus [1]