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We felt it was important to document her clinical course to inform clinicians facing similarly complex patients. Indeed, children with early-onset obesity develop insulin resistance, liver dysfunction, and beta cell decline much more rapidly than adults because their organs and metabolic systems are developing, which makes them more vulnerable to the harmful effects of excess adiposity
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Treatment with GLP-1 receptor agonists has shown a promising anti-diabetic effect in WS treatment in both animal models and in human patients
