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2003 meta-analysis: A meta-analysis of 21 clinical trials including a total of 1,204 adults with mild cognitive impairment or mild Alzheimer's disease examined the effects of 1.5 to 3.0 g/day acetyl-L-carnitine versus placebo for 3 to 12 months

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These findings highlight the importance of combining weight-loss medications with structured exercise programs to optimize functional health outcomes in adults with obesity, rather than focusing on weight reduction alone