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SCD patients have aberrant metabolic regulation of fumarate, glutamate, glycine, malate, and other metabolites involved in glycolysis, nucleotide catabolism, and glutathione metabolism 3,4,5,6

Intracellular Activity: Unlike -MSH, which acts extracellularly, KPV enters cells and directly inhibits inflammatory signaling molecules within the nucleus

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When feeding on plant species in the Apiaceae or Rutaceae families, which contain furanocoumarin- a toxic photoactive pro-oxidant, Papilio polyxenes exhibited significantly higher GST-mediated peroxidase activity