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AHK-Cu, or Alanyl-Histidyl-Lysine-Copper, substitutes alanine for glycine
In this study, five overexpressed GST isozymes (GSTA2X, GSTA3, GSTT1L, GSTZ1-1, and GSTZ1-2) of chicken alleviated the AFB 1 -induced death of LMH cell, which could be attributed to their ability in decreasing LDH activity and DNA damage as well as increasing AFBO-GSH production
Its depletion in tissue culture or animal models is used as an experimental tool to investigate oxidative stress mechanisms, while supplementation studies explore how restoration of GSH levels affects cellular function in research contexts
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