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Though we may not yet have clear answers about the specific effects of GLP-1s on mental health, we know from the patients we share that the arrows connecting obesity and mental illness point in both directions
Disruption of cysteine uptake and collapse of intracellular GSH pool induces an inhibition of the detoxifying activity of GPx4 and excessive accumulation of oxidatively damaged lipids at the membrane, although it remains unclear if this solely affects the cell plasma membrane, or the effect also extends to organelle membranes
Current Diabetes Reports
Massive Investment, Long Road It is important to note that some GLP-1 agonist drugs require a 4-6 month titration period to reach the maximum dosage while avoiding severe side effects
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