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The key variables in this analysis: what percentage of your total pharmacy spend is on generic drugs (typically 85-90% of prescription volume but only 20-30% of total drug spend), what percentage of those generics are classified as specialty by your current PBM (and thus dispensed through PBM-affiliated specialty pharmacies at inflated margins), and what is the spread between your current contracted price and Cost Plus acquisition cost for those drugs
A recent study revealed that a year after withdrawal, those patients taking GLP-1 agonists regained two-thirds of the weight loss [1]
[53] In two of these (NCT03954834 and NCT04039503), participants were randomly assigned to receive either tirzepatide or placebo injection weekly
The advisory committee focused on lab studies showing that MOTS-c has the potential to help treat obesity and osteoporosis, but there is very little evidence from human trials to support its safe, effective use
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