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Mechanistically, p62 orchestrates selective autophagy execution through ubiquitinated cargo recognition and autophagosomal translocation, ultimately enabling substrate proteolysis (111,112)

Enzym Microb Technol 3:233242 Nie W, Wei GY, Du GC, Li Y, Chen J (2005) Enhanced intracellular glutathione synthesis and excretion capability of Candida utilis by using a low pH-stress strategy

CB-839, panitumumab, and irinotecan in RAS wildtype (WT) metastatic colorectal cancer (mCRC): phase I results

For hair, PDRN is most useful in patients whose hair loss has an inflammatory or post-inflammatory component: telogen effluvium after stress, hair loss following autoimmune flares, recovery after hair transplant procedures, or scalp inflammation accompanying conditions like seborrheic dermatitis