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However, severe, persistent headaches lasting more than one week, headaches accompanied by vision changes or neurological symptoms, or headaches that worsen with continued dosing warrant immediate provider evaluation to rule out serious underlying conditions and assess medication continuation

However, the challenge with current TRPV1 antagonists lies in their associated adverse effects, such as hyperthermia 24,25,26,27,28,29,30,31 and hypothermia 32,33,34 , caused by failures in thermoregulation

The people who made it through understood the timeline, prepared for peak side effect weeks, and followed specific protocols