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These results demonstrate that d-allulose improves glucose tolerance via potentiation of GLP-1R signaling

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However, rapid pharmacologically induced weight loss may be accompanied by unfavorable body-composition changes, including reductions in lean mass, and weight regain is common following treatment discontinuation, underscoring a major durability gap

Retatrutide appeared to induce lean mass loss in similar proportions to GLP-1RAs alone, whereas PTT-A has shown robust fat reduction without significant decrease in muscle mass, highlighting the potential of selective multi-agonists to preserve skeletal muscle during weight loss [66, 67]