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TFEB is considered a master regulator of the biogenesis of lysosomes through its ability to regulate the expression of genes encoding lysosomal hydrolases and lysosomal membrane proteins

"Gastrointestinal tolerability of once-weekly semaglutide 2.4 mg in adults with overweight or obesity, and the relationship between gastrointestinal adverse events and weight loss." Diabetes, Obesity and Metabolism