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Effect of dual glgucagon-like peptide 1/glucose-dependent insulinotropic polypeptide receptor agonist (tirzepatide) versus bariatric surgery on weight loss and nonalcoholic fatty liver disease

These agents bind within deep transmembrane pockets of the receptor, often exhibit stimulatory G protein alpha subunit (Gs)-biased signaling that can limit -arrestin-driven internalization, and are designed for food-independent, once-daily dosing

The decrease in microbial diversity in these patients is primarily attributed to the significant reduction in Firmicutes , particularly within the C

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