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This latter effect has contributed to its notable impact on weight reduction, leading to increased off-label use for weight management, though Wegovy (a higher-dose formulation of semaglutide) is the preparation specifically licensed for obesity treatment in the UK
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By affecting the signaling of VEGF, excessive ROS inhibits the formation of new blood vessels, development of follicles, and production of estrogen and progesterone, and affects the appearance of luteinizing hormone peaks, ultimately leading to ovulation disorder
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