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Altered ultrastructure of mitochondrial membranes is strongly associated with unexplained asthenozoospermia

However, as reassuring as all of this is, there are a couple of things to remain mindful of: Copper toxicity Because GHK-Cu contains copper, it does pose a potential risk of copper toxicity,12 the symptoms of which include abdominal pain, vomiting, chest pain, chills, cough, fever, general weakness, anemia, burning sensations, tremors, and a metallic taste in the mouth.13 The risk is small, as the concentrations of copper in the peptide are typically well within safe parameters, but its good to be aware of it

Thus the use of AZA is now limited to patients who are unable to tolerate mycophenolate or sirolimus, or when pregnancy is planned since mycophenolate and sirolimus have significant teratogenic potential and should be avoided

David G