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The evidence base for tirzepatide as monotherapy is robust, with pivotal trials including SURMOUNT-1 demonstrating significant weight reduction in adults with obesity, and SURPASS trials establishing glycemic efficacy in type 2 diabetes
Weeks 1-4: tirzepatide only phase During the tirzepatide-only phase, the primary change is appetite reduction
Phentermine, one of the oldest weight loss drugs still in clinical use, still has its advocates
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