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Human relevance would require sufficient published, peer-reviewed controlled human studies, safety evaluation, pharmacokinetic understanding, toxicology data, and regulatory reviewevidence that has not yet been established at the level required for clinical or consumer-use conclusions

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Last, to assess the impact of missing data, we included individuals who had been excluded due to missing BMI or HbA1c at baseline and applied mean imputation for BMI, HbA1c, systolic blood pressure, eGFR and ACR within each trial, then repeated analyses for cardiovascular, kidney, liver and safety outcomes

Treatment with DQ significantly weakened this signatureas did quercetin alone comparably