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10.1136/bmj.n71 49 PageM

GLP-1 class medications caused thyroid tumors in rodent studies, but this has not been confirmed in humans

Retatrutide inherits every structural driver of discontinuation that semaglutide and tirzepatide have, and it adds one of its own: the dose-dependent dysesthesia signal at 9 mg and 12 mg in TRIUMPH-4, reported at roughly 20.9% at the 12 mg dose