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This dual action of promoting fat breakdown while simultaneously reducing fat storage creates the net effect of adipose tissue reduction, all occurring at the peripheral tissue level without involvement of central appetite-regulating pathways in the hypothalamus

A supervised gene ontology analysis using selected gene sets related with main signaling pathways of hair regeneration and growth (i.e., Wnt-, Notch-, bone morphogenetic proteins (BMP)-, and sonic hedgehog (Shh)-signaling) 3,16 to identify NTAPP-induced programs related to hair