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adults, based on nationally representative data from 20172020, and is associated with approximately $173 billion in annual medical costs, driven largely by increased rates of cardiovascular disease, diabetes, and related chronic conditions

Considering the relationship between GLP-1 signaling and behavioral symptoms characteristic of depression, it was shown that intracerebroventricular ( icv ) administration of both GLP-1 and exendin-4 enhances associative and spatial learning, while these effects are inhibited by a GLP-1R antagonist

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