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[13] Chloramphenicol has been shown to blunt reticulocyte response to cyanocobalamin, while ethanol, colchicine, and nitrous oxide interfere with cobalamin metabolism or utilization, each warranting clinician awareness when evaluating suboptimal treatment outcomes
The mean placebo-adjusted weight loss in the 12 mg arm at 48 weeks was approximately 22.1% per the published Phase 2 results
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