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By integrating metabolic regulation with inflammation suppression, SIRT1 represents a promising therapeutic target in MASLD and related inflammatory liver diseases

This regulatory effect of DMF was identified through NRF2-dependent and independent mechanisms with NRF2 binding to ARE motifs and increasing DNA 5hmC of individual gene regulatory regions involved in the TSS pathway, cystine uptake, and GSH generation

Ongoing Surveillance During Treatment Once peptide therapy is initiated, ongoing surveillance for malignancy should continue throughout the treatment period and potentially beyond, depending on treatment duration and individual risk factors