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Secondly, for detecting the HIF transcriptional activity, a dedicated HIF1 transcriptional activity assay kit (Cayman, 10006910) was used for measuring the HIF transcriptional activity, which demonstrated that the transcriptional activity of HIF1 in IDH1 wild type GSC1 and mGSCs were significantly higher than that in GSC1 transfected with IDH1 mutant vector and IDH1 mutant mGSCs, respectively (Supplementary Fig
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