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Ozempic is in the class of drugs glucagon-like peptide-1 receptor agonists, but it selectively agonizes GLP-1 receptors

In particular, the extent to which PXR-driven CYP3A4 activation contributes to mitochondrial dysfunction and apoptosis has not been fully defined

Given the very low quality of evidence for efficacy and demonstrated AEs of androgen therapy, the Work Group concluded that androgens should not be used as an adjuvant to ESA treatment in anemic patients with CKD