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The commonly cited 200500 mcg per day is more conservative and aligns with what decades of community observation and clinician experience has converged toward as a reasonable starting point
Protecting muscle during the treatment period is not just about now it determines what happens if and when the drug is stopped
A second, perhaps more practical limitation is the -opioid system has currently limited therapeutic potential in terms of treating pain, in contrast to the -opioid system
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High dose aspirin decreases SUA level by inhibiting URAT1, whereas low dose exerts urate retentive role through stimulating URAT1 (Zhang et al., 2014)
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