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doi:10.1016/j.jalz.2017.06.1086

I., et al

Toxic solvent residues DMF (dimethylformamide) Known liver toxin Associated with reproductive toxicity Must be removed to extremely low limits in GMP drugs DCM (dichloromethane / methylene chloride) Probable human carcinogen Central nervous system depressant Dangerous even in small amounts if injected TFA (trifluoroacetic acid) Corrosive Can remain in peptides as unmeasured TFA salt Pharmaceutical products often convert TFA salts to safer counterions Without validated HPLC, mass spectrometry, and residual solvent testing, patients may be injected with harmful chemical contaminants

Furthermore, defects in IFN- signaling, often due to loss-of-function mutations in JAK1/2 or STAT1, impair human leukocyte antigen (HLA) upregulation, diminish PD-L1 expression and impede T-cellmediated antitumor responses, thereby conferring resistance to ICB