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The primary mechanism by which they suppress ferroptosis, specifically on the inner mitochondrial membrane, involves the reduction of CoQ10 to its antioxidant form, CoQ10H2 (Mao et al., 2021)

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This is the first report to show that RSL3 is also synthetically lethal to the cells that harbor PIK3CA and BRAF mutation, such as K1 PTC cells

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