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Al-Sabah S, Al-Haddad M, Al-Youha S, Jamal M, Almazeedi S
As aforementioned, EMT is tightly linked to cancer stemness, metastasis, and drug resistance
135,136 The TME promotes resistance by restricting drug penetration, suppressing antitumor immunity, providing survival cytokines, maintaining CSC niches, and reinforcing immune-excluded or immune-cold states
Think of it as pressing two complementary levers at once one tells the body to make GH, the other tells it to release it
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