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In the past two decades, high quality genetic, transcriptomic, protein, enzymatic, and pharmacotherapeutic studies have consistently highlighted reduced mitochondrial function associated with bipolar depression
The concentration of L-glutamate was then calculated using a standard calibration curve, normalized to protein sample concentrations, and levels expressed as percentage relative to controls
This phenomenon is often explained by the Glutathione Depletion-Methylation Cycle Block (GD-MCB) hypothesis , originally proposed to explain how Long COVID can trigger ME/CFS
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