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Groups at increased risk of B12 deficiency include: Vegans and strict vegetarians , who avoid all animal products and are at significant risk without supplementation or fortified foods Older adults , in whom reduced stomach acid production impairs B12 absorption People with pernicious anaemia , an autoimmune condition that destroys intrinsic factor-producing cells Those who have undergone gastric surgery , including bariatric procedures, which can reduce intrinsic factor availability Individuals taking long-term metformin for type 2 diabetes, as this medication is associated with reduced B12 absorption the MHRA has issued specific safety advice on monitoring B12 levels in this group [6] [7] People with conditions affecting the small intestine , such as Crohn's disease or coeliac disease Symptoms of B12 deficiency can include fatigue, weakness, pins and needles, memory difficulties, and a sore or inflamed tongue (glossitis)

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Some foreign scholars compared the number of pancreatic cancer patients treated with exenatide and those treated with other hypoglycemic drugs, and the results revealed that the number of pancreatic cancer patients treated with exenatide was 2.9 times greater than that of patients treated with other hypoglycemic drugs (82)

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Different outcome

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Sleep apnea improvement: ZepBound is now FDA-approved for sleep apnea in people with obesity, as weight loss can ease symptoms like snoring and disrupted breathing

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