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Then, in 2015, Lee and colleagues identified a previously overlooked open reading frame within the 12S ribosomal RNA gene of mtDNA and found that it encodes a functional peptide, MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) [1]

Additionally, supporting the methylation cycle with active B-vitamins (like methylfolate and methylcobalamin) can help the body eventually resume its own endogenous production of glutathione