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Furthermore, in vitro cellular and molecular methods demonstrated that Nle-AngIV stimulated dendritic spine numbers, increased spine size, and enhanced miniature excitatory postsynaptic currents in hippocampal neurons
These findings suggest that semaglutide may also exert direct, non-weight loss-mediated effects on inflammation
These positive effects on weight loss together with the experimental evidence suggesting that liraglutide exerts its effects directly in the CNS raise the question of whether GLP-1RAs of higher molecular weights, such as dulaglutide and albiglutide, would be as effective as liraglutide in promoting weight loss [23]
As of now, long-term safety data is not available
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