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At 48 weeks, the Phase 2 trial recorded an average loss of 24.2% total body weight at the highest dose
10.1056/NEJMoa2403664 8 BrosseauL.YongeK
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Natural ghrelin is only active at GHS-R1a when it carries a specific fatty-acid modification an octanoyl (C8) group attached to its third amino acid by the enzyme ghrelin O-acyltransferase (GOAT)
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