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Experts say there are plausible albeit unconfirmed explanations, noting for example that GLP-1 medications may interfere with the efficacy of oral contraceptives or increase fertility in women because they help with weight loss
Key Takeaways Approximately 95% of serotonin is found outside the brain, primarily in the gut The gut-brain axis represents a bidirectional communication system that influences mood, digestion, and overall health GI side effects are common because SSRIs affect serotonin signaling throughout the digestive system SSRIs affect sleep through multiple mechanisms, including REM suppression and changes in sleep architecture Sexual side effects result from serotonins inhibition of dopamine and direct effects on sexual response pathways Weight changes involve complex interactions between appetite, metabolism, and recovery from depression SSRIs can affect platelets, potentially increasing bleeding risk An integrative approach supports the whole body throughout treatment, addressing gut health, nutrition, inflammation, and hormones Frequently Asked Questions Why does 95% of serotonin exist in the gut rather than the brain
Arteriosclerosis, Thromb Vasc Biol (2013) 33(5):894902
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