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General Knee Osteoarthritis or Diffuse Pain When pain is not localized to a single structure, rotate injections around all four quadrants of the knee

Peer review Peer review information Nature Medicine thanks Christiana Kartsonaki, Peter Rossing, Naveed Sattar and Vikas Sridhar for their contribution to the peer review of this work

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This is because issues with regular function of the gastrointestinal tract can prevent the proper release and absorption of the vitamin which causes deficiency