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It happens when the medication was doing 100% of the work

These studies enhance our understanding of the therapeutic potential and efficacy of GLP-1RAs in the treatment of HF

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Use In Specific Populations 8.1 Pregnancy Risk Summary Available data from clinical trials and postmarketing reports on REPATHA use in pregnant women are insufficient to evaluate for a drug-associated risk of major birth defects, miscarriage or other adverse maternal or fetal outcomes